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1.
Desalination and Water Treatment ; 288:140-150, 2023.
Article in English | Web of Science | ID: covidwho-20244861

ABSTRACT

Like all public utility, swimming pools had been treated with special procedures during the COVID19 pandemic. In addition to the basic rules (social distance + hand disinfection + masks), applicable to all citizens, the managers of swimming pools were obliged to reduce the number of swimmers and to increase the effects of water treatment. Monitoring, control and rapid response to unfavourable changes in the quality of swimming pool water are the basis for minimizing the risk of disease transmission or exposure of bathers to pathogens. The main purpose of this work is to analyse and compare the quality of swimming pool water in a municipal outdoor swimming pool complex, before (2018-2019) and during the COVID-19 pandemic (2020-2021). Water samples taken from a paddling pool for children (CP), a recreational pool (RP), and a sports pool (SP) were analysed. The results of the research, based on real case studies, were compared with the documents on water quality in swimming pools in force at the time. An analysis was carried out to determine the relationships between swimming pool water quality before and during the COVID-19 pandemic. The tested parameters determining the quality of water were physico-chemical parameters (temperature, pH, redox, and bacteriological parameters (colony forming units CFU of Pseudomonas aeruginosa, Escherichia coli, Legionella sp.). Based on the results of the analysis of the parameters mentioned-above, the validation of the procedures applied during the COVID-19 hazard and their impact on the quality of swimming pool water were evaluated. The results of the pool water quality tests were discussed with particular emphasis on disinfection by-products (THM and combined chlorine). Detailed analysis showed better water quality in the first year of the pandemic (2020) compared to 2018-2019 (before COVID-19) and 2021 (the second year of COVID-19 pandemic). The following parameters were found to be significantly different: THM (before 0.069 mg/L and during 0.034 mg/L), free chlorine (before 0.86 mg/L and during 0.66 mg/L), and redox potential (before 667 and during 713 mV).

2.
Journal of Water Resource and Protection ; 14(4):349-384, 2022.
Article in English | CAB Abstracts | ID: covidwho-2315361

ABSTRACT

In COVID-19 pandemic in the world, alcohol (ethanol) can be listed as a sterilizing disinfectant. It absolutely played a Messianic function on the sterilization effect. And it is said that it has one more function called "salinity reduction" but that function is not widely known. The two functions (Sterilization & Salinity Reduction) mentioned above are extremely important regarding the theme of "raw seawater into beverage" in this study. It is thought that if the two functions are achieved other water quality items such as NO-2 and other items can be cleared with comparative ease. To put briefly the feature of modern waterworks in a word, it can be said that "source of water is river water and its sterilization is chlorine". In this study, we set up it with a completely new sanitization method (great reset), that is, "source of water is mixtures (seawater and rainwater) and its sterilization is ethanol". And it can be also expected that the capture and storage of ethanol as a renewable resource is basically possible by utilizing sunlight as a natural power. Therefore, we think that this resolves itself into a question of the choice (sense of value/culture) of the users. It means that how users finally balance out with three factors, i.e., cost, risk (safety) and benefit. Based on the viewpoint mentioned above, we examined the possibility of raw seawater into beverage using ethanol as a renewable resource to create humankind's wisdom to the settlement (breakthrough) of the water scarcity in the world including Asia and Africa. As a result, we have obtained the new findings that suggest the possibility of raw seawater into beverage using ethanol as a renewable resource.

3.
ISME Communications ; 2(1):84, 2022.
Article in English | ProQuest Central | ID: covidwho-2313591

ABSTRACT

During the COVID-19 outbreak in Wuhan, large amounts of anti-coronavirus chemicals, such as antiviral drugs and disinfectants were discharged into the surrounding aquatic ecosystem, causing potential ecological damage. Here, we investigated plankton in the Wuhan reaches of the Yangtze River, before, during, and after COVID-19, with the river reaches of three adjacent cities sampled for comparison. During the COVID-19, planktonic microbial density declined significantly. Correspondingly, the eukaryotic and prokaryotic community compositions and functions shifted markedly, with increasing abundance of chlorine-resistant organisms. Abundance of antibiotic resistance genes, virulence factor genes, and bacteria containing both genes increased by 2.3-, 2.7-, and 7.9-fold, respectively, compared to other periods. After COVID-19, all measured plankton community compositional and functional traits recovered in the Yangtze River.

4.
Environ Sci Technol ; 57(21): 7913-7923, 2023 05 30.
Article in English | MEDLINE | ID: covidwho-2315445

ABSTRACT

Antiviral transformation products (TPs) generated during wastewater treatment are an environmental concern, as their discharge, in considerable amounts, into natural waters during a pandemic can pose possible risks to the aquatic environment. Identification of the hazardous TPs generated from antivirals during wastewater treatment is important. Herein, chloroquine phosphate (CQP), which was widely used during the coronavirus disease-19 (COVID-19) pandemic, was selected for research. We investigated the TPs generated from CQP during water chlorination. Zebrafish (Danio rerio) embryos were used to assess the developmental toxicity of CQP after water chlorination, and hazardous TPs were estimated using effect-directed analysis (EDA). Principal component analysis revealed that the developmental toxicity induced by chlorinated samples could be relevant to the formation of some halogenated TPs. Fractionation of the hazardous chlorinated sample, along with the bioassay and chemical analysis, identified halogenated TP387 as the main hazardous TP contributing to the developmental toxicity induced by chlorinated samples. TP387 could also be formed in real wastewater during chlorination in environmentally relevant conditions. This study provides a scientific basis for the further assessment of environmental risks of CQP after water chlorination and describes a method for identifying unknown hazardous TPs generated from pharmaceuticals during wastewater treatment.


Subject(s)
COVID-19 , Water Pollutants, Chemical , Animals , Disinfection/methods , Chlorine/analysis , Zebrafish , Water Pollutants, Chemical/toxicity , Water Pollutants, Chemical/analysis , COVID-19 Drug Treatment , Water
5.
Water Res ; 239: 120020, 2023 Jul 01.
Article in English | MEDLINE | ID: covidwho-2307866

ABSTRACT

Environment disinfection effectively curbs transmission of the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). However, elevated concentration of free available chlorine (FAC) in disinfectants can be discharged into surface water, generating toxic disinfection byproducts (DBPs). The impact of solar photolysis of FAC on natural organic matter (NOM) to form DBPs has not been well studied. In this work, solar photolysis of FAC was found to result in higher formation of DBPs, DBPs formation potential (DBPsFP), total organic chlorine (TOCl) and lower specific ultraviolet absorbance at 254 nm (SUVA254), compared to dark chlorination. In solar photolysis of FAC, formation of total DBPs was promoted by pH=8, but hindered by the addition of HCO3-, radical scavenger or deoxygenation, while addition of NO3-and NH4+both enhanced the formation of nitrogenous DBPs. Differences in the formation of DBPs in solar photolysis of FAC under various conditions were influenced by reactive species. The formation of trichloromethane (TCM) and haloacetic acids (HAAs) in solar photolysis of FAC positively correlated with the steady-state concentrations of ClO• and O3. The steady-state concentrations of •NO and •NH2 positively correlated with the formation of halonitromethanes (HNMs). HAAs and haloacetonitriles (HANs) mainly contributed to calculated cytotoxicity of DBPs. This study demonstrates that solar photolysis of FAC may significantly impact the formation of DBPs in surface water due to extensive use of disinfectants containing FAC during SARS-CoV-2 pandemic.


Subject(s)
COVID-19 , Disinfectants , Water Pollutants, Chemical , Water Purification , Humans , Disinfection , Chlorine , Photolysis , SARS-CoV-2 , Halogenation , Water , Water Pollutants, Chemical/analysis
6.
19th China International Forum on Solid State Lighting and 8th International Forum on Wide Bandgap Semiconductors, SSLCHINA: IFWS 2022 ; : 228-230, 2023.
Article in English | Scopus | ID: covidwho-2306504

ABSTRACT

Recent studies in the epidermis have shown that Far-UVC (200-230nm) is a promising candidate against Novel Coronavirus (SARS-Cov-2) with little DNA damage. Due to the consideration that conventional Far-UVC KrCl excilamps may emit 200-230 nm radiation (typically 222-nm peak wavelength) but with some harmful UV radiation beyond 230 to 280 nm, a novel design of Far-UVC KrCl excilamps with the filter and reflector is introduced to reduce the harmful UV radiation from 10.9% to 2.5% at the cost of 30%~40% reduction in the total irradiance. In our study, the radiant characteristics and service life of the novel Far-UVC KrCl excilamps of 40~75 Watt (electrical power) with 222-nm peak wavelength were investigated. The service life was assessed under aging at the ambient temperatures (Ta) of 25 and 85 for 500 hours, respectively. The results showed that both the ambient temperature and the root mean square of current (Irms) into the excilamps have a substantial effect on the lifetime of the KrCl excilamps. Furthermore, although no significant change of the off-nominal emission ratio existed during the lifetime test, it was observed that the high ambient temperature has a negative effect on the filtering of the harmful radiation. © 2023 IEEE.

7.
Brain and Neuroscience Advances ; 7(1):65-71, 2021.
Article in English | ProQuest Central | ID: covidwho-2306434

ABSTRACT

To date, only a few cases of intracranial infection related to severe acute respiratory syndrome‐coronavirus‐2 (SARS‐CoV‐2) were reported. Here we describe a case of coronavirus disease 2019 (COVID‐19) that was comorbid with purulent meningitis. A 62‐year‐old male patient was diagnosed with moderate COVID‐19 and had no fever or cough after treatment. However, he suffered from a head injury and experienced headache and fever immediately after the accident. Computed tomography (CT) of the brain showed bilateral frontal lobe contusion, subdural hematoma, and subarachnoid hemorrhage. In the following days, the patient suffered from recurrent fever, although chest CT did not show evidence of worsening of infection. Several lumbar punctures were made, confirming increased cerebrospinal fluid (CSF) pressure and karyocyte count. SARS‐CoV‐2 nucleic acid was not detected in CSF but revealed the presence of Escherichia coli. Thus, the patient was diagnosed with purulent meningitis, presumably caused by brain trauma or the immunologic dysfunction caused by COVID‐19, which was supported by the significant reduction of all kinds of immune cells. Since immunologic dysfunction is commonly presented in COVID‐19 patients, comorbidity with meningitis should be considered when a COVID‐19 patient presents with headache and fever. Lumbar punctures and CSF cultures may help in the diagnosis.

8.
Applied Organometallic Chemistry ; 2023.
Article in English | Scopus | ID: covidwho-2300741

ABSTRACT

Four copper (II) complexes bearing tris-(2-pyridyl)-pyrazolyl borate (Tppy) ligand with corresponding chloride (Cu-1), aqua (Cu-2), azide (Cu-3), and thiocyanide (Cu-4) substitutions were synthesized and characterized by spectroscopic and analytical methods. Spectroscopic and molecular docking studies were employed to investigate the interactions of these complexes with calf thymus (CT) DNA and bovine serum albumin (BSA). The results inferred intercalation binding mode of the complexes with DNA. All the complexes exhibited good binding with BSA as well. In addition, the binding efficacy of the Cu (II) complexes with SARS-Cov-2 was tested in silico. Further, in vitro anticancer activity of the complexes was investigated against the HeLa-cervical, HepG2-liver and A549-lung cancer, and one normal (L929-fibroblast) cell line. IC50 values unveiled that the complexes were more active than cisplatin against all three cancer cells. It was understood that complex Cu-3 containing azide substitution displayed the highest activity on the HeLa cell line (IC50 = 6.3 μM). More importantly, TppyCu (II) complexes were not active against the normal cell line. Lastly, the acridine orange/ethidium bromide (AO/EB) and 4′,6-diamidino-2-phenylindole staining assays indicated that Cu-3 induced cell death in HeLa cells at the late apoptotic stage. This complex also efficiently generated ROS in HeLa cells promoting apoptosis as understood from the DCFH-DA assay. © 2023 John Wiley & Sons, Ltd.

9.
New Journal of Chemistry ; 46(39):18824-18831, 2022.
Article in English | EMBASE | ID: covidwho-2295520

ABSTRACT

The study of tautomerism in biologically relevant heterocycles is essential, as it directly affects their chemical properties and biological function. Lactam-lactim tautomerization in pyridine/pyrazine derivatives is such a phenomenon. Favipiravir, a pyrazine derivative, is an essential antiviral drug molecule having notable performance against SARS-CoV-2. Along with a better yielding synthetic method for favipiravir, we have also investigated the lactam-lactim tautomerization of favipiravir and its analogous molecules. Most of these molecules were crystalized and studied for various interactions in their lattice. Many interesting supramolecular interactions such as hydrogen bonding, pi-pi stacking and halogen bonding were revealed during the analysis. Some of these structures show interesting F-F halogen bonding and water channels in their solid state.Copyright © 2022 The Royal Society of Chemistry.

10.
Int J Environ Res Public Health ; 20(8)2023 04 14.
Article in English | MEDLINE | ID: covidwho-2299074

ABSTRACT

Legionella is a pathogen that colonizes soils, freshwater, and building water systems. People who are most affected are those with immunodeficiencies, so it is necessary to monitor its presence in hospitals. The purpose of this study was to evaluate the presence of Legionella in water samples collected from hospitals in the Campania region, Southern Italy. A total of 3365 water samples were collected from January 2018 to December 2022 twice a year in hospital wards from taps and showers, tank bottoms, and air-treatment units. Microbiological analysis was conducted in accordance with the UNI EN ISO 11731:2017, and the correlations between the presence of Legionella and water temperature and residual chlorine were investigated. In total, 708 samples (21.0%) tested positive. The most represented species was L. pneumophila 2-14 (70.9%). The serogroups isolated were 1 (27.7%), 6 (24.5%), 8 (23.3%), 3 (18.9%), 5 (3.1%), and 10 (1.1%). Non-pneumophila Legionella spp. represented 1.4% of the total. Regarding temperature, the majority of Legionella positive samples were found in the temperature range of 26.0-40.9 °C. An influence of residual chlorine on the presence of the bacterium was observed, confirming that chlorine disinfection is effective for controlling contamination. The positivity for serogroups other than serogroup 1 suggested the need to continue environmental monitoring of Legionella and to focus on the clinical diagnosis of other serogroups.


Subject(s)
Legionella pneumophila , Legionella , Humans , Chlorine/analysis , Water Supply , Hospitals , Environmental Monitoring , Water/analysis , Water Microbiology
11.
Front Cell Infect Microbiol ; 13: 1061647, 2023.
Article in English | MEDLINE | ID: covidwho-2290912

ABSTRACT

Background: Reprocessing and disinfecting endoscopes is a routine practice in otolaryngology. An effective, safe, and rapid disinfection technique is essential during the COVID-19 pandemic. Objective: To validate the efficacy of chlorine dioxide wipes in disinfecting three types of airway endoscopes contaminated with COVID-19-positive patient secretions. Methods: Chlorine dioxide wipes were tested on rigid nasal endoscopes, laryngoscope blades, and flexible bronchoscopes. The endoscopes were disinfected using the wipes after exposure to COVID-19-positive patients. The tested scope was included in the study if the post procedure pre disinfection swab was positive for COVID-19 virus using RT-PCR. We analyzed 38 samples for 19 subjects (scopes) pre and post disinfection with chlorine dioxide wipes from July 2021 to February 2022. Results: A total of four rigid endoscopes, four flexible bronchoscopes, and four laryngoscopes were included in the study which represent 24 pre and post disinfection swabs. The others were excluded because of negative pre disinfection swab. All the post disinfection PCR swab results were negative. Conclusion: Chlorine dioxide is a convenient, fast, and effective disinfection technique for COVID-19-contaminated airway endoscopes.


Subject(s)
COVID-19 , Pandemics , Humans , Pandemics/prevention & control , COVID-19/prevention & control , Disinfection/methods
12.
European Journal of Molecular and Clinical Medicine ; 7(9):3924-3929, 2020.
Article in English | EMBASE | ID: covidwho-2277892

ABSTRACT

Introduction- Electrolyte balance of the body is maintained by renin angiotensin aldosterone system. Some previous studies suggested that COVID-19 is associated with gastrointestinal symptoms, such as diarrhea and vomiting. This may results in electrolyte disturbances in patients. Electrolytes in body like sodium (Na), potassium (K). Chloride (Cl) plays an important physiological role in maintaining acid base and water balance of cells of the body. Aims and objectives: Our study aimed to compare some electrolyte between covid 19 and non-covid patients retrospectively. Material(s) and Method(s): This retrospective study included total 57 males and 43 females in the age group of 28 to 65 years. The results were compared with 100 age and sex matched healthy controls. Estimation of serum electrolytes was done with the collected venous blood samples using the ion selective electrode technique in an electrolyte analyzer. Analysis was done using SPSS V 25 Software. Chi-square and t-test were used to see association and difference between two variable respectively. Result(s): We have found that covid 19 is associated with low levels of electrolytes like Na, K, Cl. Chloride levels in both the groups was not statistically significant. But Hyponatremia and Hypokalemia were observed in cases group with high statical Signficance. Conclusion(s): Study found that electrolytes deterioration in these patients play a critical role in patients management. Thus a monitoring of electrolyte is essential throughout their illness to manage covid patients to improve their quality of life.Copyright © 2020 Ubiquity Press. All rights reserved.

13.
Revista Higiene Alimentar ; 36(295), 2022.
Article in Portuguese | CAB Abstracts | ID: covidwho-2272726

ABSTRACT

Recently, with the coronavirus pandemic, the eating habits of the population have been modified, observing the search for healthy diet. In this sense, the consumption of fruits and vegetables has increased, and the hygiene is a fundamental step in quality control, since fruits and vegetables can be consumed in natura. The objective of the work was to elaborate a review about the main chemical sanitizers used in the sanitization of fruits and vegetables. The study is a review based on scientific publications, using the combination of the following descriptors: hygiene, fruits and vegetables, sanitizers and sanitizing. It was possible to verify that the most used sanitizer in the sanitization of fruits and vegetables is chlorine and its derivatives, in concentrations from 100 to 200 ppm, normally for 15 minutes. Ozone could destroy numerous microorganisms and for its sanitizing effect it is necessary to have a longer exposure time, on average up to 30 minutes. When using organic acids (acetic, citric, lactic and peracetic acid), the concentrations vary up to 2% and the average exposure time is a few minutes, which can be used in combination or not. However, its use is not always effective. It is concluded that the application of each type of sanitizer varies according to its concentrations, pH, exposure time to the treatment and the type of fruit or vegetable to be sanitized.

14.
Applied Sciences ; 13(4):2119, 2023.
Article in English | ProQuest Central | ID: covidwho-2270989

ABSTRACT

If it is not adequately managed, the waste from healthcare facilities containing infectious material poses a risk to the general public and the natural environment. As a result, hospitals must ensure that their waste management policies do not add to the dangers posed to both human health and the environment. In this study, we aimed to determine the effect that varying doses of disinfectant in conjunction with andosol soil had on the total number of bacteria present in the medical waste generated by three hospitals in Semarang City, Indonesia. According to the findings of the study, the most efficient method for decreasing the overall number of microbial colonies by 93% was a combination involving soil (at a percentage of 30) and chlorine (at a concentration of 0.75 ppm). As a consequence of this, and due to the limited technology available, this straightforward method can become an alternative for the healthcare industry in managing medical waste before dumping or incinerating it. Hospitals have been advised to discontinue the practice of directly burning, disinfecting, or transporting waste to disposal locations before it receives treatment. This can help reduce the risk of pandemics, as the correct disposal of medical waste can control infection sources.

15.
6th International Conference on Electronics, Communication and Aerospace Technology, ICECA 2022 ; : 270-274, 2022.
Article in English | Scopus | ID: covidwho-2252081

ABSTRACT

Coronavirus (COVID-19) is an infectious illness due to serious respiratory trouble. It is impacted numerous humans and has asserted the living expectancy of a greater number of persons from all over the planet. The maturation period of this virus, on typically about 5-6 days but it might also be up to 2 weeks. Throughout this period, the individual may not feel any indications but could still be transmissible. A person could develop this disease if he/ she inhales the virus while a diseased person/ virus carrier within close vicinity sneezes or coughs otherwise tapping an infected place in addition to afterward again his/ her eyes, nose or mouth. To prevent this, the region of the COVID-19 patient must be decontaminated with virucidal disinfectants, such as and 0.05% sodium hypochlorite (NaClO) and ethanol-based products (at least 70%) an optional technique used is UV light sterilization. Ultraviolet (UV) sterilization technology is used to help reduce micro-organisms that can remain on surfaces after basic sprinkling to the minimum amount. The proposed work has established an UV robot or UV bot to perform decontamination in an operating room or in-patients room. Three 19.3-watt UV lights are positioned in a 360-degree circle on the UV bot platform. It used an integrated system based on a microprocessor and a metal frame to aid in navigation in a fixed path to avoid barriers. In addition, a sanitizer dispenser is also included to clean the viral organisms, which is spread through the water droplets of the patient. © 2022 IEEE.

16.
Oral Dis ; 2021 Oct 12.
Article in English | MEDLINE | ID: covidwho-2281108

ABSTRACT

OBJECTIVE: To determine the in vitro antiviral activity of oral care products containing stabilized chlorine dioxide toward infectious viruses that harbor in the oral cavity. Specfically, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), SARS-CoV, human coronavirus (HCoV) 229E, influenza A (H3N2), rhinovirus type 14, adenovirus type 5, and herpes simplex virus (HSV) type 1 and 2 were examined. METHODS: Validated in vitro suspension virucidal assays were used. Test product was mixed with the test virus for 30, 60, or 120 s, neutralized with sodium thiosulfate, serially diluted in dilution medium in a 96-well plate and incubated in a carbon dioxide incubator for 7 days. The 50% Tissue Culture Infectious Dose per milliliter was determined. RESULTS: Two rinses, one oral spray and one fluoride toothpaste showed log reduction of severe acute respiratory syndrome coronavirus-2 ranging from 1.81 to 2.98 and of influenza A from 2.58 to 4.13, respectively, within 30 s of contact time; similar results were obtained at 60 s. Further, the Ultra Sensitive rinse showed 0.19, 0.75, 1.58, 1.75, 2.66, and 3.24 log reduction of severe acute respiratory syndrome coronavirus, human coronavirus 229E, rhinovirus type 14, adenovirus type 5, and herpes simplex virus type 1 and type 2, respectively, within 30 s of contact time. CONCLUSION: Stabilized chlorine dioxide containing CloSYS® oral care products reduced the viral load of multiple viruses within 30 s. The results warrant further investigation for potential in vivo applications.

17.
Journal of Environmental Sciences (China) ; 135:198-209, 2024.
Article in English | Scopus | ID: covidwho-2264687

ABSTRACT

Quaternary ammonium compounds (QACs) are commonly used in a variety of consumer and commercial products, typically as a component of disinfectants. During the COVID-19 pandemic, QACs became one of the primary agents utilized to inactivate the SARS-CoV-2 virus on surfaces. However, the ecotoxicological effects of QACs upon aquatic organisms have not been fully assessed. In this study, we examined the effects of a widely used QAC (benzalkonium chloride-C14, BAC-14) on two toxigenic Microcystis strains and one non-toxigenic freshwater Microcystis strain and carried out an analysis focused on primary, adaptive and compensatory stress responses at apical (growth and photosynthesis) and metabolic levels. This analysis revealed that the two toxic Microcystis strains were more tolerant than the non-toxic strain, with 96 hr-EC50 values of 0.70, 0.76, and 0.38 mg/L BAC-14 for toxigenic M. aeruginosa FACHB-905, toxigenic M. aeruginosa FACHB-469, and non-toxigenic M. wesenbergii FACHB-908, respectively. The photosynthetic activities of the Microcystis, assessed via Fv/Fm values, were significantly suppressed under 0.4 mg/L BAC-14. Furthermore, this analysis revealed that BAC-14 altered 14, 12, and 8 metabolic pathways in M. aeruginosa FACHB-905, M. aeruginosa FACHB-469, and M. wesenbergii FACHB-908, respectively. It is noteworthy that BAC-14 enhanced the level of extracellular microcystin production in the toxigenic Microcystis strains, although cell growth was not significantly affected. Collectively, these data show that BAC-14 disrupted the physiological and metabolic status of Microcystis cells and stimulated the production and release of microcystin, which could result in damage to aquatic systems. © 2022

18.
Annals of Clinical and Analytical Medicine ; 14(3):276-280, 2023.
Article in English | EMBASE | ID: covidwho-2263042

ABSTRACT

Aim: In this study, we aimed tto compare the 30-day mortality prediction abilities of the acute physiology and chronic health evaluation II (APACHE II), CURB-65, pneumonia severity index (PSI), A-DROP, Infectious Diseases Society of America/American Thoracic Society severity criteria, and I-ROAD scores in patients aged over 80 years admitted to the intensive care unit with COVID-19 pneumonia. Material(s) and Method(s): The study was conducted with a single-center retrospective observational design and included patients aged 80 years and older who were admitted to the intensive care unit due to COVID-19 pneumonia between March 2020 and August 2021. Patient demographic data, imaging findings, blood test results, discharge status, length of stay in the intensive care unit, duration of mechanical ventilation, inotropic drug administration status, presence/ absence of mortality and vital signs at the time of admission were obtained from the hospital automation system. Then, the above-mentioned scores were calculated and compared statistically. Result(s): The study was completed with 119 patients, 60 (50.4%) women and 59 (49.6%) men. The mean age of all patients was 84 (80-98) years, and the mortality rate was 84.03% (n=100). Among the scoring systems, I-ROAD had the highest area under the curve (AUC) value (0.703), APACHE II had the highest specificity (94%), and A-DROP had the highest sensitivity (64%). Discussion(s): According to our results, the I-ROAD scoring system is an effective tool that can be used in the prediction of mortality related to COVID-19 pneumonia among intensive care patients aged >=80.Copyright © 2023, Derman Medical Publishing. All rights reserved.

19.
Soil Ecology Letters ; 5(1):66-78, 2023.
Article in English | Scopus | ID: covidwho-2246635

ABSTRACT

Chlorine-containing disinfectants have been widely used around the world for the prevention and control of the COVID-19 pandemic. However, at present, little is known about the impact of residual chlorine on the soil micro-ecological environment. Herein, we treated an experimental soil-plant-microbiome microcosm system by continuous irrigation with a low concentration of chlorine-containing water, and then analyzed the influence on the soil microbial community using metagenomics. After 14-d continuous chlorine treatment, there were no significant lasting effect on soil microbial community diversity and composition either in the rhizosphere or in bulk soil. Although metabolic functions of the rhizosphere microbial community were affected slightly by continuous chlorine treatment, it recovered to the original status. The abundance of several resistance genes changed by 7 d and recovered by 14 d. According to our results, the chlorine residue resulting from daily disinfection may present a slight long-term effect on plant growth (shoot length and fresh weight) and soil micro-ecology. In general, our study assisted with environmental risk assessments relating to the application ofchlorine-containing disinfectants and minimization of risks to the environment during disease control, such as COVID-19. © 2022, Higher Education Press.

20.
Alexandria Engineering Journal ; 62:193-210, 2023.
Article in English | Scopus | ID: covidwho-2245748

ABSTRACT

The mucus fluid vehicle is impacted by the synthetic response that changes the physical science of liquid due to the thickness of the bodily fluid. Additionally, various issues in the respiratory system might happen because of bodily fluid adequacy. A central point of transportation of immunizations to forestall COVID-19 is the concentration level expected during movement, stockpiling, and dispersion. The current review stated that mucus fluid transportation is restrained through magnetic force originating due to heat variation. Permeable channel over respiratory disease and chemicals due to mass reaction–diffusion variation. The bodily fluid development is surveyed by the force, energy, and diffusion condition influence of body powers because of attractive field, source of heat cause of thermal conduction, resistance due to disease chemical reaction cause of concentration profile. The nonlinear arrangement of incomplete differential conditions is addressed by the Laplace transform technique, and MATLAB programming outcomes are initiated for momentum, temperature, and diffusion fields and inferred that the bodily fluid stream decelerates due to magnetic force. The skin friction, Nusselt number, Sherwood number, and the microorganism's thickness are assessed and explained exhaustively. Furthermore, microorganisms are occupied in different elements to survey the mucus fluid mechanism. © 2022

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